Download e-book for iPad: A Mathematical Approach to Multilevel, Multiscale Health by Rodrick Wallace,Deborah Wallace

By Rodrick Wallace,Deborah Wallace

This publication, in keeping with released reports, takes a different standpoint at the 30-year cave in of pharmaceutical productiveness within the look for small molecule “magic bullet” interventions. The relentless escalation of inflation-adjusted fee in step with authorized medication within the usa — from $200 million in 1950 to $1.2 billion in 2010 — has pushed giants to, at top, slavish imitation in drug layout, and at worst, abandonment of study and embracing of common fraud in shopper marketing.

The e-book adapts formalism throughout a few disciplines to the tactic for layout of mutilevel interventions, focusing first on molecular, mobile, and bigger scale examples, after which extending the argument to the simplifications supplied by means of the dominant function of social and cultural buildings and methods in person and inhabitants styles of well-being and illness.

In position of “magic bullets”, we needs to now observe “magic techniques” that act throughout either the dimensions and point of association. This ebook offers an introductory roadmap to the recent instruments that might be wanted for the layout of such strategies.

Contents:

  • Beyond Magic Bullets
  • Expanding the Theory
  • Dynamic ‘Regression Models’
  • An Evolutionary Excursion
  • Example: psychological Disorders
  • Example: Protein Folding
  • Example: Glycome Determinants
  • Example: Glycan/Lectin common sense Gates
  • Example: IDP good judgment Gates
  • Treatment
  • History and Health
  • Beyond Glasperlenspiel
  • Mathematical Appendix

Readership: Undergraduate, graduate, researchers and pros in biomathematics, biostatistics, mathematical modeling, advanced platforms and pharmaceuticals.

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A Mathematical Approach to Multilevel, Multiscale Health Interventions:Pharmaceutical Industry Decline and Policy Response by Rodrick Wallace,Deborah Wallace


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